Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657066 | 1.00 | P4HTM (0.54) | P4HTMPIM2PTGS2ESR1MAPT | |
| SCHEMBL4619798 | 0.98 | P4HTM (0.53) | P4HTMPIM2PTGS2ESR1MAPT | |
| SCHEMBL7482002 | 0.87 | PIM2 (0.54) | P4HTMPIM2ESR1MAPTALDH1A1 | |
| SCHEMBL3786486 | 0.87 | PIM2 (0.54) | P4HTMPIM2ESR1MAPTAOC3 | |
| SCHEMBL7482012 | 0.87 | PIM2 (0.54) | P4HTMPIM2ESR1MAPTALDH1A1 | |
| SCHEMBL29551688 | 0.87 | PIM2 (0.54) | P4HTMPIM2ESR1MAPTAOC3 | |
| SCHEMBL3786488 | 0.87 | PIM2 (0.54) | P4HTMPIM2ESR1MAPTAOC3 | |
| SCHEMBL16789345 | 0.86 | PTGS2 (0.49) | P4HTMPIM2PTGS2MAPTUBE2T | |
| SCHEMBL4622159 | 0.82 | CA12 (0.47) | PTGS2MAPTAOC3ALDH1A1LMNA | |
| SCHEMBL28395325 | 0.81 | CA12 (0.52) | PTGS2ESR1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462047-B1 | CONTAINING 5- OR 6-MEMBERED OXYGEN, NITROGEN AND/OR SULFUR HETEROARYL GROUP; ANGINA, HYPERTENSION, RESPIRATORY DISTRESS, CONGESTIVE HEART FAILURE, RENAL FAILURE, ATHEROSCLEROSIS, INFLAMMATORY DISEASES, STROKES, BRONCHITIS, ASTHMA | ICOS CORPORATION | 2002-10-08 | — | — | US | disclosed |