Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.30 |
| ▸ | REN | P00797 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057176 | 1.00 | F2 (0.32) | F2F10ALDH1A1MMP13MMP3 | |
| SCHEMBL7060192 | 0.89 | GRIN2B (0.32) | ALDH1A1MMP13MMP3MMP1MMP2 | |
| SCHEMBL7056677 | 0.88 | KMT2A (0.33) | ALDH1A1MMP13MMP3KMT2AMEN1 | |
| SCHEMBL7057619 | 0.88 | ALDH1A1 (0.36) | ALDH1A1MMP13MMP1KMT2AMEN1 | |
| SCHEMBL7059005 | 0.86 | ALDH1A1 (0.36) | ALDH1A1MMP13MMP3KMT2AMEN1 | |
| SCHEMBL7054421 | 0.86 | ALDH1A1 (0.36) | ALDH1A1MMP13MMP3MMP1KMT2A | |
| SCHEMBL7353510 | 0.86 | REN (0.31) | REN | |
| SCHEMBL7056516 | 0.86 | POLB (0.32) | ALDH1A1MMP13KMT2AMEN1LMNA | |
| SCHEMBL7353809 | 0.85 | MMP8 (0.40) | F2F10MMP3MMP1MMP2 | |
| SCHEMBL7060309 | 0.85 | ALDH1A1 (0.38) | ALDH1A1MMP3MMP1MMP2MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489324-B2 | TREATING STROKE, ARHTRITIS, CANCER, TISSUE ULCERATION, DECUBITIS ULCER, RESTENOSIS, PERIODONTAL DISEASE, EPIDERMOLYSIS BULLOSA, SCLERITIS, PSORIASIS, AIDS, SEPSIS, AND SEPTIC SHOCK. | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| US-6333324-B1 | FOR THERAPY AND PROPHYLAXIS OF MATRIX METALLOPROTEINASES (MMP) OR TUMOR NECROSIS FACTOR .ALPHA. (TNF.ALPHA.), MEDIATED DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-12-25 | — | — | US | disclosed |