Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659419 | 0.90 | NAAA (0.44) | CLPPCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7428183 | 0.84 | LTB4R2 (0.44) | CLPPCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7698402 | 0.83 | CHRNB2 (0.52) | CLPPCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7659831 | 0.83 | KDM4E (0.48) | MEN1KMT2ALMNAHTTNPSR1 | |
| SCHEMBL7428250 | 0.82 | KCNA5 (0.44) | CLPPCAPN1MEN1KMT2A | |
| SCHEMBL7696167 | 0.81 | CAPN1 (0.57) | CAPN1FNTAFNTB | |
| SCHEMBL7697277 | 0.76 | CAPN1 (0.47) | CAPN1KMT2A | |
| SCHEMBL7696690 | 0.75 | CAPN1 (0.54) | CAPN1TACR3 | |
| SCHEMBL18086870 | 0.74 | CHRNB2 (0.52) | CHRNB2CHRNB4CHRNA3CHRNA4MEN1 | |
| SCHEMBL7666903 | 0.73 | KDM4E (0.47) | MEN1KMT2ALMNAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |