Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677650 | 0.83 | POLB (0.53) | POLBGAAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL8087280 | 0.83 | POLB (0.53) | POLBGAAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL8092003 | 0.83 | POLB (0.53) | POLBGAAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL6425809 | 0.81 | GPR119 (0.47) | HCRTR1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL9282435 | 0.79 | POLB (0.56) | POLBGAAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL7814725 | 0.79 | POLB (0.54) | POLBBRD4GAAMAPTSMN1; SMN2 | |
| SCHEMBL7652347 | 0.76 | HCRTR1 (0.51) | HCRTR1MAPTSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL7660437 | 0.75 | HCRTR1 (0.55) | HCRTR1 | |
| SCHEMBL7677473 | 0.74 | SIGMAR1 (0.60) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7663736 | 0.73 | HCRTR1 (0.49) | HCRTR1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407093-B1 | (3,4-DIHYDRO-2H-BENZOTHIOPYRAN-4-YL)-HOMOPIPERAZINE DERIVATIVES; ANTIISCHEMIC AGENTS; ALZHEIMER*S AND PARKINSON*S DISEASE, AIDS RELATED DEMENTIA, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS | ASTRAZENECA UK LIMITED (GB) | 2002-06-18 | — | — | US | disclosed |
| EP-1051416-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | AstraZeneca UK Limited (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999038863-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | ASTRAZENECA UK LIMITED (GB) | 1999-08-05 | — | — | WO | disclosed |