Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6422733 | 0.81 | GPR119 (0.46) | ALDH1A1KDM4ESMN1; SMN2OPRL1 | |
| SCHEMBL8092003 | 0.80 | POLB (0.53) | POLBALDH1A1MAPTKDM4EGAA | |
| SCHEMBL8087280 | 0.80 | POLB (0.53) | POLBALDH1A1MAPTKDM4EGAA | |
| SCHEMBL7677650 | 0.80 | POLB (0.53) | POLBALDH1A1MAPTKDM4EGAA | |
| SCHEMBL7657291 | 0.79 | POLB (0.52) | POLBALDH1A1MAPTTSHRGAA | |
| SCHEMBL7814997 | 0.76 | CHRNA7 (0.43) | TSHRCYP2C19SMN1; SMN2OPRL1 | |
| SCHEMBL9282435 | 0.76 | POLB (0.56) | POLBALDH1A1MAPTKDM4EGAA | |
| SCHEMBL7677473 | 0.74 | SIGMAR1 (0.60) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7832801 | 0.73 | OPRL1 (0.40) | OPRL1 | |
| SCHEMBL6002215 | 0.73 | OPRL1 (0.45) | ALDH1A1TSHRSMN1; SMN2OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140891-A1 | 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040574-A1 | 1,4-DIAZACYCLOHEPTANE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | ASTRAZENECA AB (SE) | 2000-07-13 | — | — | WO | disclosed |