Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 2/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.31 |
| ▸ | DDX3X | O00571 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653334 | 0.89 | AGTR1 (0.33) | BRS3AGTR1AGTR2 | |
| SCHEMBL7654238 | 0.86 | BRS3 (0.36) | BRS3 | |
| SCHEMBL7650730 | 0.85 | APLNR (0.34) | AGTR1AGTR2DDX3X | |
| SCHEMBL7657701 | 0.85 | GSK3B (0.30) | AGTR1AGTR2 | |
| SCHEMBL7654064 | 0.85 | APLNR (0.33) | AGTR2 | |
| SCHEMBL7924623 | 0.84 | DDX3X (0.33) | DDX3X | |
| SCHEMBL7654688 | 0.84 | — | — | |
| SCHEMBL7652695 | 0.83 | — | — | |
| SCHEMBL7655666 | 0.82 | APLNR (0.35) | — | |
| SCHEMBL7656066 | 0.80 | BRS3 (0.33) | BRS3AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |