Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658593 | 0.84 | CNR2 (0.38) | ALDH1A1NPC1RAB9AMMELMNA | |
| SCHEMBL7655301 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4ENPC1RAB9AMME | |
| SCHEMBL7657495 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KDM4ENPC1RAB9AMME | |
| SCHEMBL7655289 | 0.78 | ALDH1A1 (0.44) | ALDH1A1KDM4ENPC1RAB9AMME | |
| SCHEMBL13164714 | 0.76 | GRM5 (0.56) | ALDH1A1KDM4ENPC1RAB9AP4HTM | |
| SCHEMBL28453112 | 0.74 | FOLH1 (0.44) | — | |
| SCHEMBL7659871 | 0.74 | LMNA (0.45) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL7653658 | 0.74 | KDM4E (0.44) | ALDH1A1KDM4EPOLB | |
| SCHEMBL7650766 | 0.74 | CTSA (0.35) | LMNA | |
| SCHEMBL13210632 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KDM4ENPC1RAB9AP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |