Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.33 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.33 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.33 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.33 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.33 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.33 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.33 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.33 |
| ▸ | LONP1 | P36776 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657510 | 0.84 | ALDH1A1 (0.45) | MMELMNAALDH1A1POLBNPC1 | |
| SCHEMBL7650766 | 0.82 | CTSA (0.35) | CNR2CCR1CNR1HPGDLMNA | |
| SCHEMBL7658603 | 0.79 | MME (0.39) | CNR2MMECNR1PSMB5PSMB11 | |
| SCHEMBL7659871 | 0.79 | LMNA (0.45) | CNR2HPGDLMNAALDH1A1POLB | |
| SCHEMBL7653658 | 0.75 | KDM4E (0.44) | HPGDALDH1A1POLBATML3MBTL1 | |
| SCHEMBL7105347 | 0.75 | CNR1 (0.46) | CNR2MMECNR1 | |
| SCHEMBL7104649 | 0.73 | CNR1 (0.44) | CNR2MMECCR1CNR1PSMB5 | |
| SCHEMBL18130942 | 0.73 | LMNA (0.45) | CNR2CNR1LMNANPC1RAB9A | |
| SCHEMBL18130920 | 0.73 | LMNA (0.45) | CNR2CNR1LMNANPC1RAB9A | |
| SCHEMBL18130968 | 0.73 | LMNA (0.45) | CNR2CNR1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |