Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539336 | 0.90 | KDM4E (0.60) | KDM4EHTTRAB9ANPC1CA1 | |
| SCHEMBL7655831 | 0.87 | KDM4E (0.56) | KDM4EHTTRAB9ANPC1CA1 | |
| SCHEMBL7655169 | 0.86 | KDM4E (0.67) | KDM4EHTTRAB9ANPC1CA1 | |
| SCHEMBL7655246 | 0.83 | KDM4E (0.50) | KDM4EHTTALDH1A1DRD2KMT2A | |
| SCHEMBL382963 | 0.83 | SMYD3 (0.43) | KDM4EHTTALDH1A1GFERDRD2 | |
| SCHEMBL7655291 | 0.81 | KDM4E (0.53) | KDM4EHTTRAB9ANPC1HDAC6 | |
| SCHEMBL7658795 | 0.81 | KDM4E (0.55) | KDM4EHTTRAB9ANPC1CA1 | |
| SCHEMBL6375221 | 0.80 | RAB9A (0.67) | KDM4EHTTRAB9ANPC1CA1 | |
| SCHEMBL7657964 | 0.79 | KDM4E (0.52) | KDM4EHTTRAB9ANPC1CA1 | |
| SCHEMBL7049509 | 0.78 | ITGB3 (0.42) | KDM4EHTTRAB9ANPC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |