Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.48 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658774 | 1.00 | NPC1 (0.60) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7662631 | 0.97 | NPC1 (0.56) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7662637 | 0.97 | NPC1 (0.56) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7663395 | 0.84 | NPC1 (0.56) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7663402 | 0.84 | NPC1 (0.56) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7672232 | 0.80 | RAB9A (0.49) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7672237 | 0.80 | RAB9A (0.49) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7669618 | 0.79 | NPC1 (0.51) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7662571 | 0.79 | FAAH (0.52) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7669612 | 0.79 | NPC1 (0.51) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355641-B1 | HYPOTENSIVE AGENTS AND WOUND HEALING AGENTS | SYNTEX (U.S.A.) LLC | 2002-03-12 | — | — | US | disclosed |
| WO-2000055143-A1 | OXAZOLONE DERIVATIVES AND THEIR USE AS ALPHA-1 ADRENORECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-09-21 | — | — | WO | disclosed |