Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.51 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663402 | 1.00 | NPC1 (0.56) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7662571 | 0.88 | FAAH (0.52) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7662567 | 0.88 | FAAH (0.52) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7669612 | 0.86 | NPC1 (0.51) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7669618 | 0.86 | NPC1 (0.51) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7669622 | 0.86 | ADRA1A (0.63) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7668853 | 0.85 | LMNA (0.51) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7668858 | 0.85 | LMNA (0.51) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7658770 | 0.84 | NPC1 (0.60) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 | |
| SCHEMBL7658774 | 0.84 | NPC1 (0.60) | NPC1RAB9AHPGDSMN1; SMN2DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355641-B1 | HYPOTENSIVE AGENTS AND WOUND HEALING AGENTS | SYNTEX (U.S.A.) LLC | 2002-03-12 | — | — | US | disclosed |
| WO-2000055143-A1 | OXAZOLONE DERIVATIVES AND THEIR USE AS ALPHA-1 ADRENORECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-09-21 | — | — | WO | disclosed |