Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfanilamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.42 |
| ▸ | CA12 | O43570 | 6/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6869002 | 0.82 | NLRP3 (0.45) | CA2NLRP3 | |
| SCHEMBL27430354 | 0.81 | NLRP3 (0.44) | CA2NLRP3 | |
| Sulfanilamide SCHEMBL419065 | 0.76 | CA2 (0.74) | CA2CA12CA9CA1CA14 | |
| SCHEMBL3637984 | 0.69 | CA2 (0.55) | CA2CA12CA9CA1CA14 | |
| Sulfanilamide SCHEMBL7766519 | 0.69 | CA2 (0.61) | CA2CA12CA9CA1CA14 | |
| SCHEMBL19506100 | 0.68 | NLRP3 (0.46) | CA2NLRP3 | |
| Sulfanilamide SCHEMBL629179 | 0.67 | CA2 (0.77) | CA2CA12CA9CA1CA14 | |
| Sulfanilamide SCHEMBL2215151 | 0.67 | CA2 (0.77) | CA2CA12CA9CA1CA14 | |
| Sulfanilamide SCHEMBL28201481 | 0.67 | CA2 (0.85) | CA2CA12CA9CA1CA14 | |
| Sulfanilamide SCHEMBL28706270 | 0.65 | CA2 (0.55) | CA2CA12CA9CA1CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214087-A1 | COMBINATION TREATMENT WITH IL-1RA AND COMPOUNDS THAT INHIBIT IL-1 PROCESSING AND RELEASE | Pfizer Products Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019390-A1 | COMBINATION TREATMENT WITH IL-1RA AND DIARYL SULPHONYL UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2001-03-22 | — | — | WO | disclosed |
| US-6022984-A | Efficient synthesis of furan sulfonamide compounds useful in the synthesis of new IL-1 inhibitors | PFIZER INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0976742-A1 | A synthesis of furan sulfonamide compounds useful in the synthesis of IL-1 inhibitors | Pfizer Products Inc. (US) | 2000-02-02 | — | — | EP | disclosed |