Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.71 |
| ▸ | TP53 | P04637 | 8/20 | 0.71 |
| ▸ | CSNK2A2 | P19784 | 7/20 | 0.71 |
| ▸ | CSNK2B | P67870 | 7/20 | 0.71 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | CASP1 | P29466 | 2/20 | 0.69 |
| ▸ | CASP7 | P55210 | 2/20 | 0.69 |
| ▸ | CDK2 | P24941 | 6/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | RECQL | P46063 | 3/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12378689 | 0.89 | MEN1 (0.75) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL6770344 | 0.88 | MAPT (0.67) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL28457641 | 0.86 | MAPT (0.71) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL12590664 | 0.86 | MAPT (0.84) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL12590223 | 0.86 | MAPT (0.84) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL505584 | 0.86 | MEN1 (0.79) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7657770 | 0.84 | MEN1 (0.68) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL10037939 | 0.84 | MEN1 (0.76) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7655634 | 0.83 | MEN1 (0.68) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7652737 | 0.83 | MEN1 (0.68) | MAPTTP53CSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103929959-A | Neuroprotective polyphenol analogs | SALK INST FOR BIOLOGICAL STUDI | 2014-07-16 | — | — | CN | claimed |
| US-20140186329-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-07-03 | — | — | US | claimed |
| US-20140186328-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2014-07-03 | — | — | US | claimed |
| EP-2741609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | Salk Institute for Biological Studies (US) | 2014-06-18 | — | — | EP | claimed |
| WO-2013025484-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | LAPCHAK PAUL A (US) | 2013-02-21 | — | — | WO | claimed |
| WO-2013025498-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SCHUBERT DAVID R (US) | 2013-02-21 | — | — | WO | claimed |
| EP-1109800-A1 | NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE | LG CHEMICAL LIMITED (KR) | 2001-06-27 | — | — | EP | claimed |
| WO-2000012496-A1 | NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE | LG CHEMICAL LTD. (KR) | 2000-03-09 | — | — | WO | claimed |
| US-9744164-B2 | Neuroprotective polyphenol analogs | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-08-29 | — | — | US | disclosed |
| US-9744164-B2 | Neuroprotective polyphenol analogs | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-08-29 | — | — | US | disclosed |
| US-9744164-B2 | Neuroprotective polyphenol analogs | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2017-08-29 | — | — | US | disclosed |
| US-20160206609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-07-21 | — | — | US | disclosed |
| US-20160206609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-07-21 | — | — | US | disclosed |
| US-20160206609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-07-21 | — | — | US | disclosed |
| US-20090258939-A1 | PYRONE ANALOG COMPOSITIONS AND METHODS | LIMERICK BIOPHARMA, INC. | 2009-10-15 | — | — | US | disclosed |
| WO-2009018350-A1 | PYRONE ANALOG COMPOSITIONS AND METHODS | LIMERICK BIOPHARMA, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009018320-A1 | PYRONE ANALOG COMPOSITIONS AND METHODS | LIMERICK BIOPHARMA, INC. (US) | 2009-02-05 | — | — | WO | disclosed |
| US-6500846-B1 | 2-(4-CHLOROPHENYL)-7-METHOXYCHROMEN-4-ONE, AS CYCLIN-DEPENDENT KINASE INHIBITORS, USED AS ANTICARCINOGENIC AGENTS OR FOR PROPHYLAXIS OF NEURODEGENERATIVE DISEASE | LG CHEMICAL, LTD. (KR) | 2002-12-31 | — | — | US | disclosed |
| EP-1109800-A1 | NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE | LG CHEMICAL LIMITED (KR) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012496-A1 | NOVEL CDK INHIBITORS HAVING FLAVONE STRUCTURE | LG CHEMICAL LTD. (KR) | 2000-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140186329-A1 | POLYPHENOL ANALOGS TO TREAT ISCHEMIA | GPX1, KEAP1, GPX4 | MAPT 3438/4885TP53 1653/4885CSNK2A2 4845/4885 |
| US-20090258939-A1 | PYRONE ANALOG COMPOSITIONS AND METHODS | CYP11B2, CYP11B1, GLS2 | MAPT 2788/4885TP53 578/4885CSNK2A2 2956/4885 |
| US-20140186328-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | GSR, IAPP, GCLC | MAPT 68/4885TP53 721/4885CSNK2A2 4874/4885 |
| US-20160206609-A1 | NEUROPROTECTIVE POLYPHENOL ANALOGS | GSR, IAPP, GCLC | MAPT 68/4885TP53 721/4885CSNK2A2 4874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.