Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7660448 | 0.85 | PNP (0.37) | MAPT | |
| SCHEMBL7105228 | 0.82 | PNP (0.33) | — | |
| SCHEMBL7652140 | 0.82 | PNP (0.39) | MAPT | |
| SCHEMBL7650291 | 0.77 | POLB (0.42) | MAPTSMN1; SMN2LIN28ATDP1 | |
| SCHEMBL7661935 | 0.72 | ESR1 (0.30) | — | |
| SCHEMBL7658480 | 0.72 | GRIN2D (0.36) | MAPTSMN1; SMN2LIN28ATDP1 | |
| SCHEMBL7650781 | 0.72 | TSHR (0.30) | — | |
| SCHEMBL7109245 | 0.72 | — | — | |
| SCHEMBL7653615 | 0.70 | PDCD1 (0.40) | MAPT | |
| SCHEMBL7658936 | 0.70 | KMT2A (0.45) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |