Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 4/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7541901 | 0.81 | ITGB3 (0.51) | ITGB3ITGA2BITGAVROCK2 | |
| SCHEMBL7659474 | 0.80 | ITGB3 (0.49) | ITGB3ITGA2BITGAVNAMPTBRD4 | |
| SCHEMBL7545780 | 0.77 | ITGB3 (0.59) | ITGB3ITGA2BITGAVLMNA | |
| SCHEMBL2571876 | 0.75 | ROCK2 (0.48) | NAMPTROCK2ROCK1HDAC8AAK1 | |
| SCHEMBL7441878 | 0.75 | ITGB3 (0.53) | ITGB3ITGA2BITGAV | |
| SCHEMBL7333252 | 0.74 | ITGB3 (0.52) | ITGB3ITGA2BITGAV | |
| SCHEMBL2786534 | 0.73 | ITGB3 (0.52) | ITGB3ITGA2BITGAVLMNAOPRM1 | |
| SCHEMBL2786598 | 0.73 | ITGB3 (0.52) | ITGB3ITGA2BITGAVLMNAOPRM1 | |
| SCHEMBL7335166 | 0.72 | ITGB3 (0.49) | ITGB3ITGA2BITGAVLMNA | |
| SCHEMBL7543230 | 0.71 | ITGB3 (0.46) | ITGB3ITGA2BITGAVNAMPTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762882-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-09-11 | — | — | EP | claimed |
| EP-0762882-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-03-19 | — | — | EP | claimed |
| WO-1996000574-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-11 | — | — | WO | claimed |
| US-6458784-B1 | PHARMACEUTICALLY ACTIVE BENZODIAZAPINE COMPOUNDS OF FORMULA (I) ARE DISCLOSED. THESE COMPOUNDS INHIBIT THE VITRONECTIN RECEPTOR AND ARE USEFUL FOR TREATMENT OF OSTEOPOROSIS. | SMITHKLINE BEECHAM CORPORATION | 2002-10-01 | — | — | US | disclosed |
| EP-0762882-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-0762882-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1996000574-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-11 | — | — | WO | disclosed |