Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | APLNR | P35414 | 8/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7659925 | 0.90 | ACHE (0.43) | ACHEPPARGAPLNRAGTR1TRPA1 | |
| SCHEMBL7657853 | 0.88 | PPARG (0.39) | ACHEPPARGAPLNRAGTR1TRPA1 | |
| SCHEMBL7650700 | 0.86 | PPARG (0.37) | ACHEPPARGAPLNRAGTR1TRPA1 | |
| SCHEMBL7651418 | 0.83 | PPARG (0.36) | ACHEPPARGAPLNRAGTR1TRPA1 | |
| SCHEMBL7654069 | 0.83 | APLNR (0.35) | ACHEPPARGAPLNRAGTR1TRPA1 | |
| SCHEMBL7650735 | 0.79 | PPARG (0.39) | ACHEPPARGAPLNRAGTR1TRPA1 | |
| SCHEMBL7659947 | 0.79 | ACHE (0.38) | ACHEPPARGAPLNRAGTR1TRPA1 | |
| SCHEMBL7657723 | 0.76 | APLNR (0.32) | APLNR | |
| SCHEMBL7653662 | 0.75 | APLNR (0.34) | APLNR | |
| SCHEMBL8298258 | 0.68 | AGTR1 (0.54) | PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |