Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2554648 | 0.85 | HTT (0.67) | HTTNPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL4528391 | 0.84 | HTT (0.66) | HTTNPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL27768478 | 0.81 | CHRNB2 (0.63) | NPC1SMN1; SMN2RAB9AMAPTTP53 | |
| SCHEMBL3233714 | 0.80 | HTT (0.71) | HTTNPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL3419014 | 0.80 | NPC1 (0.52) | HTTNPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL4751192 | 0.80 | HTT (0.67) | HTTSMN1; SMN2MAPTLMNAKMT2A | |
| SCHEMBL1815822 | 0.79 | CHRNB2 (0.61) | NPC1SMN1; SMN2RAB9AMAPTTP53 | |
| SCHEMBL17476086 | 0.79 | HTT (0.59) | HTTNPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL22619755 | 0.79 | HTT (0.66) | HTTNPC1SMN1; SMN2RAB9AMAPT | |
| SCHEMBL31039805 | 0.79 | HTT (0.66) | HTTNPC1SMN1; SMN2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465462-B1 | COGNITION ENHANCEMENT FOR DEMENTING ILLNESSES SUCH AS ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. | 2002-10-15 | — | — | US | disclosed |