Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.63 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.63 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PPARA | Q07869 | 6/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1815822 | 0.89 | CHRNB2 (0.61) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL3418996 | 0.84 | GAA (0.57) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL1432036 | 0.84 | MKNK1 (0.57) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL27768533 | 0.81 | NR1H4 (0.57) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL3419014 | 0.81 | NPC1 (0.52) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL7659667 | 0.81 | HTT (0.60) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL27789974 | 0.80 | MAPT (0.56) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL1422890 | 0.78 | CHRNB2 (1.00) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL4313968 | 0.76 | RAB9A (0.59) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 | |
| SCHEMBL14427066 | 0.75 | NPC1 (0.47) | CHRNB2CHRNA5CHRNA4SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102850324-A | Indole compounds | MICROBIA INC | 2013-01-02 | — | — | CN | disclosed |
| CN-101563337-A | Indole compounds | MICROBIA INC (US) | 2009-10-21 | — | — | CN | disclosed |