Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 8/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664087 | 1.00 | ADRA1A (0.53) | ADRA1AADRA1DADRA1BLMNANPSR1 | |
| SCHEMBL7658023 | 1.00 | ADRA1A (0.53) | ADRA1AADRA1DADRA1BLMNANPSR1 | |
| SCHEMBL7660469 | 0.86 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BLMNANPSR1 | |
| SCHEMBL7662361 | 0.83 | ADRA1A (0.58) | ADRA1AADRA1DADRA1BLMNANPSR1 | |
| SCHEMBL7660734 | 0.78 | ADRA1D (0.42) | ADRA1AADRA1DADRA1B | |
| SCHEMBL7660499 | 0.77 | ADRA1D (0.43) | ADRA1AADRA1DADRA1BHTR7 | |
| SCHEMBL7667964 | 0.76 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BLMNAPOLB | |
| SCHEMBL7667781 | 0.76 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BLMNAPOLB | |
| SCHEMBL7656196 | 0.76 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BLMNAPOLB | |
| SCHEMBL7668994 | 0.75 | ADRA1D (0.41) | ADRA1AADRA1DADRA1BLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | claimed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | claimed |
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | disclosed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |