Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7664056 | 0.99 | DRD2 (0.45) | DRD2ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL7655701 | 0.84 | ADRA1A (0.47) | DRD2ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL8164638 | 0.84 | DRD2 (0.51) | DRD2ADRA1AADRA1DADRA1BOPRM1 | |
| Hydrochloric Acid SCHEMBL7662752 | 0.83 | ADRA1A (0.47) | DRD2ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL7665768 | 0.81 | DRD2 (0.66) | DRD2ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL7994398 | 0.81 | ADRA1A (0.49) | DRD2ADRA1AADRA1DADRA1BHRH1 | |
| SCHEMBL7662399 | 0.81 | ADRA1A (0.45) | ADRA1AADRA1DADRA1BOPRM1 | |
| Hydrochloric Acid SCHEMBL7658312 | 0.80 | DRD2 (0.64) | DRD2ADRA1AADRA1DADRA1BOPRM1 | |
| SCHEMBL7662448 | 0.80 | OPRM1 (0.53) | ADRA1AADRA1DADRA1BOPRM1HRH1 | |
| Hydrochloric Acid SCHEMBL7664053 | 0.80 | ADRA1A (0.44) | ADRA1AADRA1DADRA1BOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | claimed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | claimed |
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | disclosed |
| WO-2000025782-A1 | DIHYDROPYRIDINONES AND PYRROLINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |