Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7661 | 1.00 | ALDH1A1 (0.51) | ALDH1A1RECQLLMNAMAPTHPGD | |
| SCHEMBL5748 | 0.92 | ALDH1A1 (0.48) | ALDH1A1RECQLLMNAMAPTHPGD | |
| SCHEMBL5746 | 0.92 | ALDH1A1 (0.48) | ALDH1A1RECQLLMNAMAPTHPGD | |
| SCHEMBL11909636 | 0.90 | ALDH1A1 (0.52) | ALDH1A1RECQLLMNAMAPTHPGD | |
| SCHEMBL11909631 | 0.90 | ALDH1A1 (0.52) | ALDH1A1RECQLLMNAMAPTHPGD | |
| SCHEMBL6263 | 0.87 | KAT2B (0.44) | ALDH1A1LMNAMAPTTRPV1MEN1 | |
| SCHEMBL6261 | 0.87 | KAT2B (0.44) | ALDH1A1LMNAMAPTTRPV1MEN1 | |
| SCHEMBL5904 | 0.85 | NPY5R (0.42) | MAPTMAPK1KMT2A | |
| SCHEMBL5906 | 0.85 | NPY5R (0.42) | MAPTMAPK1KMT2A | |
| SCHEMBL10321 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |