Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670841 | 0.81 | SRD5A1 (0.40) | NOTUMCES1POLBALDH1A1KDM4E | |
| SCHEMBL68594 | 0.72 | NOTUM (0.72) | NOTUMPOLBALDH1A1KDM4EGLA | |
| SCHEMBL5126303 | 0.72 | SMN1; SMN2 (0.68) | NOTUMCES1POLBSMN1; SMN2GAA | |
| SCHEMBL7663992 | 0.72 | P2RX4 (0.41) | POLBSMN1; SMN2GAAALDH1A1KDM4E | |
| SCHEMBL2609255 | 0.71 | ALDH1A1 (0.43) | SMN1; SMN2NOX1ALDH1A1KDM4EALOX15 | |
| SCHEMBL642025 | 0.68 | NOTUM (0.70) | NOTUMPOLBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8140930 | 0.67 | ALDH1A1 (0.72) | NOTUMCES1POLBSMN1; SMN2GAA | |
| Acetic Acid SCHEMBL29684240 | 0.66 | NOTUM (0.52) | NOTUMCES1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL11752800 | 0.66 | GLA (0.50) | NOTUMPOLBSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL19269127 | 0.66 | RAB9A (0.39) | NOTUMSMN1; SMN2GAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |