Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664012 | 0.81 | NOTUM (0.45) | SRD5A1CES1LMNAMAPTKMT2A | |
| SCHEMBL7663992 | 0.75 | P2RX4 (0.41) | SRD5A1LMNAMAPTKMT2ARAB9A | |
| SCHEMBL2609255 | 0.74 | ALDH1A1 (0.43) | SRD5A1LMNAKMT2ARAB9AALDH1A1 | |
| SCHEMBL13703838 | 0.74 | MAPT (0.35) | LMNAMAPTKMT2ARAB9AALDH1A1 | |
| SCHEMBL69754 | 0.71 | NOTUM (0.46) | SRD5A1TTRCES1LMNAMAPT | |
| SCHEMBL19269127 | 0.69 | RAB9A (0.39) | SRD5A1LMNAMAPTKMT2AMAPK1 | |
| SCHEMBL6362813 | 0.68 | KMT2A (0.54) | SRD5A1CES1LMNAKMT2ARAB9A | |
| SCHEMBL21311767 | 0.67 | CES1 (0.47) | SRD5A1TTRCES1LMNAMAPT | |
| SCHEMBL1253936 | 0.66 | RAB9A (0.47) | SRD5A1TTRCES1LMNAMAPT | |
| SCHEMBL4420931 | 0.66 | DDB1 (0.46) | GABRA1GABRG2GABRB3GABRA5CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |