Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9315092 | 0.81 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19TSHRMAPT | |
| SCHEMBL7661760 | 0.80 | CYP1A2 (0.73) | CYP1A2CYP2D6CYP2C19TSHRMAPT | |
| SCHEMBL8267406 | 0.79 | MEN1 (0.72) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6795234 | 0.78 | HTT (0.62) | CYP1A2ACKR3MAPTALDH1A1MEN1 | |
| SCHEMBL4582840 | 0.78 | PTPN1 (0.63) | CYP1A2CYP2D6CYP2C19TSHRACKR3 | |
| SCHEMBL30791550 | 0.76 | PTPN1 (0.61) | CYP1A2CYP2D6CYP2C19TSHRACKR3 | |
| SCHEMBL951041 | 0.76 | PTPN1 (0.61) | CYP1A2CYP2D6CYP2C19TSHRACKR3 | |
| SCHEMBL30683706 | 0.76 | LMNA (0.53) | CYP1A2CYP2C19ACKR3MAPTALDH1A1 | |
| SCHEMBL29114917 | 0.76 | LMNA (0.53) | CYP1A2CYP2C19ACKR3MAPTALDH1A1 | |
| SCHEMBL4156900 | 0.76 | ALDH1A1 (0.67) | CYP1A2ACKR3MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369070-B1 | Methods for inhibiting mrp1 | ELI LILLY AND COMPANY | 2002-04-09 | — | — | US | disclosed |
| EP-1067928-A4 | METHODS FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1067928-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999051228-A1 | METHODS FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 1999-10-14 | — | — | WO | disclosed |