Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | PTPRG | P23470 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PTPRC | P08575 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7542204 | 0.87 | MAPK8 (0.39) | NTRK1NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7664571 | 0.86 | NTRK1 (0.48) | NTRK1PTPRGALDH1A1HPGD | |
| SCHEMBL7545477 | 0.85 | PTPRC (0.44) | NTRK1NPC1RAB9AGFERALDH1A1 | |
| SCHEMBL7550361 | 0.84 | MAPK8 (0.43) | NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL7539246 | 0.84 | NTRK1 (0.41) | NTRK1ALDH1A1HPGD | |
| SCHEMBL7541519 | 0.83 | MAPK8 (0.42) | HPGD | |
| SCHEMBL7540773 | 0.80 | MAPK8 (0.39) | NTRK1NPC1RAB9AGFERALDH1A1 | |
| SCHEMBL7655178 | 0.78 | PTPRC (0.49) | NTRK1PTPRGNPC1RAB9AGFER | |
| SCHEMBL7546778 | 0.78 | CCNE2 (0.43) | NTRK1NPC1RAB9AGFERALDH1A1 | |
| SCHEMBL9067875 | 0.78 | PTPRC (0.48) | PTPRGALDH1A1HPGDPTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | claimed |
| EP-1187826-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2002-03-20 | — | — | EP | claimed |
| WO-2000071532-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-11-30 | — | — | WO | claimed |
| US-6380214-B1 | THIOPHENE-3-CARBOXYLIC ACID AMIDE DERIVATIVES | PFIZER INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1187826-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000071532-A1 | HETEROCYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2000-11-30 | — | — | WO | disclosed |