Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903117 | 0.81 | TSHR (0.46) | HRH3KMT2ALMNATSHR | |
| SCHEMBL316101 | 0.78 | TAAR1 (0.48) | TAAR1GAANR1H2NR1H3NPC1 | |
| SCHEMBL1723556 | 0.78 | TAAR1 (0.48) | TAAR1GAANR1H2NR1H3NPC1 | |
| SCHEMBL6971912 | 0.75 | HRH3 (0.51) | HRH3KMT2ATSHR | |
| SCHEMBL24787891 | 0.74 | RIPK1 (0.40) | TAAR1 | |
| SCHEMBL3695497 | 0.74 | DDAH1 (0.31) | ADORA2AADORA1 | |
| SCHEMBL5850108 | 0.73 | KDM4E (0.42) | GAANPC1POLBRAB9AKMT2A | |
| SCHEMBL10650713 | 0.73 | TAAR1 (0.47) | TAAR1GAANR1H2NR1H3NPC1 | |
| SCHEMBL7936430 | 0.73 | TAAR1 (0.47) | TAAR1GAANR1H2NR1H3NPC1 | |
| SCHEMBL5469222 | 0.73 | TAAR1 (0.47) | TAAR1GAANR1H2NR1H3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |