Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 9/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566543 | 0.85 | GABRA2 (0.48) | GABRA2GABRB2MLYCDMEN1MAPT | |
| SCHEMBL7534386 | 0.85 | GABRA2 (0.48) | GABRA2GABRB2MLYCDMEN1MAPT | |
| SCHEMBL7664658 | 0.81 | MAPK9 (0.61) | GABRA2GABRB2MLYCDMEN1MAPT | |
| SCHEMBL7665202 | 0.80 | MAPK14 (0.51) | GABRA2GABRB2MAPK9 | |
| SCHEMBL7661360 | 0.80 | GABRA2 (0.45) | GABRA2GABRB2MLYCDMEN1MAPT | |
| SCHEMBL7665192 | 0.80 | MAPK14 (0.51) | GABRA2GABRB2MAPK9 | |
| SCHEMBL7665100 | 0.78 | GABRA2 (0.45) | GABRA2GABRB2MLYCDMEN1MAPT | |
| SCHEMBL20384716 | 0.71 | KDM4E (0.54) | GABRA2GABRB2MEN1MAPTKMT2A | |
| SCHEMBL10958938 | 0.69 | FAAH (0.54) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL30504042 | 0.69 | FAAH (0.54) | MEN1MAPTKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492516-B1 | PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF WHICH EXHIBIT UTILITY FOR THE TREATMENT OF CYTOKINE MEDIATED DISEASES SUCH AS ARTHRITIS. | MERCK & CO., INC. | 2002-12-10 | — | — | US | disclosed |