Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188963 | 0.82 | ACHE (0.47) | MAPK1L3MBTL1ALDH1A1ACHEMEN1 | |
| SCHEMBL8221443 | 0.73 | MEN1 (0.44) | MAPK1L3MBTL1ALDH1A1ACHEMEN1 | |
| SCHEMBL5399245 | 0.70 | MEN1 (0.50) | MAPK1L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL9035419 | 0.70 | ACHE (0.46) | MAPK1L3MBTL1ALDH1A1ACHEMEN1 | |
| SCHEMBL9036456 | 0.66 | ACHE (0.42) | MAPK1L3MBTL1ALDH1A1ACHEMEN1 | |
| SCHEMBL29469601 | 0.66 | MAPK1 (0.71) | MAPK1L3MBTL1ALDH1A1TDP1TSHR | |
| SCHEMBL28687305 | 0.66 | ALDH1A1 (0.49) | MAPK1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL29948190 | 0.66 | ALDH1A1 (0.49) | MAPK1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL899494 | 0.65 | MAPK1 (1.00) | MAPK1L3MBTL1ALDH1A1TDP1TSHR | |
| SCHEMBL29367556 | 0.65 | MAPK1 (1.00) | MAPK1L3MBTL1ALDH1A1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |