Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585968 | 0.96 | ALDH1A1 (0.39) | ALDH1A1ALOX5APFEN1GPR119EPHX2 | |
| SCHEMBL7676310 | 0.93 | ALDH1A1 (0.42) | ALDH1A1ALOX5APFEN1GPR119EPHX2 | |
| SCHEMBL6584996 | 0.91 | ALDH1A1 (0.41) | ALDH1A1ALOX5APFEN1GPR119EPHX2 | |
| SCHEMBL7478777 | 0.88 | ALOX5AP (0.39) | ALDH1A1ALOX5APFEN1GPR119CHRNB4 | |
| SCHEMBL6587429 | 0.88 | KDM4E (0.45) | ALDH1A1ALOX5AP | |
| SCHEMBL7134497 | 0.87 | CHRNA3 (0.39) | ALDH1A1ALOX5APFEN1GPR119CHRNB4 | |
| SCHEMBL6584732 | 0.86 | ALOX5AP (0.39) | ALDH1A1ALOX5APFEN1GPR119CHRNB4 | |
| SCHEMBL6585517 | 0.85 | MAPT (0.40) | ALDH1A1 | |
| SCHEMBL7470605 | 0.84 | ALOX5AP (0.41) | ALDH1A1ALOX5APFEN1GPR119CHRNB4 | |
| SCHEMBL7667587 | 0.84 | ALOX5AP (0.37) | ALDH1A1ALOX5APFEN1GPR119CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6437138-B1 | 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |