Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 7/20 | 0.72 |
| ▸ | PLAU | P00749 | 1/20 | 0.66 |
| ▸ | HPN | P05981 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 8/20 | 0.57 |
| ▸ | MMP3 | P08254 | 4/20 | 0.57 |
| ▸ | MMP13 | P45452 | 4/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7676199 | 1.00 | MMP9 (0.72) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL7668182 | 0.91 | MMP9 (0.72) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL7673418 | 0.91 | MMP9 (0.72) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL3969625 | 0.88 | MMP9 (0.71) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL7066619 | 0.88 | MMP9 (0.71) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL11351046 | 0.88 | MMP9 (0.71) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL6929743 | 0.86 | MMP9 (0.72) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL7673449 | 0.85 | PLAU (0.59) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL7674329 | 0.85 | PLAU (0.59) | MMP9PLAUHPNMMP2MMP3 | |
| SCHEMBL5093780 | 0.84 | MMP9 (1.00) | MMP9PLAUHPNMMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |