Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 8/20 | 0.72 |
| ▸ | MMP2 | P08253 | 8/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MMP3 | P08254 | 5/20 | 0.59 |
| ▸ | MMP13 | P45452 | 5/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.59 |
| ▸ | MMP7 | P09237 | 1/20 | 0.59 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | HPN | P05981 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673418 | 1.00 | MMP9 (0.72) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL7667679 | 0.91 | MMP9 (0.72) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL7676199 | 0.91 | MMP9 (0.72) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL7673536 | 0.86 | MMP9 (0.57) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL7665170 | 0.86 | MMP9 (0.57) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL7669251 | 0.85 | MMP9 (0.76) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL7669603 | 0.85 | MMP9 (0.76) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL15251688 | 0.85 | MMP2 (0.64) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL9603327 | 0.85 | MMP2 (0.64) | MMP9MMP2LMNAMMP3MMP13 | |
| SCHEMBL7062840 | 0.85 | MMP2 (0.64) | MMP9MMP2LMNAMMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |