Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.59 |
| ▸ | HPN | P05981 | 2/20 | 0.59 |
| ▸ | MMP9 | P14780 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674329 | 1.00 | PLAU (0.59) | PLAUHPNMMP9LMNAMEN1 | |
| SCHEMBL7673536 | 0.91 | MMP9 (0.57) | PLAUHPNMMP9LMNAMEN1 | |
| SCHEMBL7665170 | 0.91 | MMP9 (0.57) | PLAUHPNMMP9LMNAMEN1 | |
| SCHEMBL7667625 | 0.88 | MMP9 (0.57) | PLAUHPNMMP9LMNAMEN1 | |
| SCHEMBL7670593 | 0.86 | LMNA (0.55) | PLAUHPNMMP9LMNAMEN1 | |
| SCHEMBL7673629 | 0.85 | MMP9 (0.76) | PLAUHPNMMP9MAPTKDM4E | |
| SCHEMBL5090722 | 0.85 | MMP9 (0.76) | PLAUHPNMMP9MAPTKDM4E | |
| SCHEMBL7676199 | 0.85 | MMP9 (0.72) | PLAUHPNMMP9LMNAMEN1 | |
| SCHEMBL7667679 | 0.85 | MMP9 (0.72) | PLAUHPNMMP9LMNAMEN1 | |
| SCHEMBL7671437 | 0.84 | MMP9 (0.59) | PLAUHPNMMP9LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |