Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670521 | 0.90 | MEN1 (0.57) | KMT2AMEN1LMNASMN1; SMN2F2 | |
| SCHEMBL5092484 | 0.90 | MEN1 (0.55) | KMT2AMEN1LMNASMN1; SMN2TDP1 | |
| SCHEMBL7667880 | 0.90 | LMNA (0.54) | KMT2AMEN1LMNASMN1; SMN2TDP1 | |
| SCHEMBL7667916 | 0.89 | F2 (0.52) | KMT2AMEN1LMNASMN1; SMN2TSHR | |
| SCHEMBL7671859 | 0.89 | PRMT1 (0.56) | KMT2AMEN1LMNASMN1; SMN2F2 | |
| SCHEMBL7663740 | 0.88 | ALDH1A1 (0.65) | KMT2AMEN1LMNASMN1; SMN2F2 | |
| SCHEMBL7582747 | 0.88 | LMNA (0.65) | KMT2AMEN1LMNASMN1; SMN2F2 | |
| SCHEMBL6799380 | 0.88 | ALDH1A1 (0.56) | KMT2AMEN1LMNASMN1; SMN2TSHR | |
| SCHEMBL7670801 | 0.88 | LMNA (0.52) | LMNASMN1; SMN2F2TMPRSS6ALDH1A1 | |
| SCHEMBL7580808 | 0.88 | HSD17B10 (0.61) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |