Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 16/20 | 0.62 |
| ▸ | MLYCD | O95822 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL766505 | 0.89 | MLYCD (0.52) | TRPV1MLYCDMAPTKDM4EMEN1 | |
| SCHEMBL13256885 | 0.89 | MLYCD (0.52) | TRPV1MLYCDMAPTKDM4EMEN1 | |
| SCHEMBL1686546 | 0.86 | MLYCD (0.56) | TRPV1MLYCDMAPTKDM4EMEN1 | |
| SCHEMBL766527 | 0.86 | MLYCD (0.56) | TRPV1MLYCDMAPTKDM4EMEN1 | |
| SCHEMBL766796 | 0.85 | TRPV1 (0.68) | TRPV1MLYCDMAPT | |
| SCHEMBL766830 | 0.84 | TRPV1 (0.55) | TRPV1MLYCDMAPTKDM4EMEN1 | |
| SCHEMBL1686248 | 0.84 | TRPV1 (0.62) | TRPV1MLYCD | |
| SCHEMBL766536 | 0.82 | TRPV1 (0.65) | TRPV1 | |
| SCHEMBL1686294 | 0.81 | MLYCD (0.51) | TRPV1MLYCDMAPTKDM4EMEN1 | |
| SCHEMBL472899 | 0.77 | GSK3B (0.55) | MLYCDMAPTKDM4EMEN1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
| EP-2393789-A1 | ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010091009-A1 | ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |
| WO-2010091009-A1 | ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, TRPV3 | TRPV1 1/4885MLYCD 2174/4885MAPT 2229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.