Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | SNRNP200 | O75643 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672566 | 0.93 | BRD4 (0.37) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7665153 | 0.90 | KCNA5 (0.35) | PKMMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7672401 | 0.89 | MEN1 (0.31) | PKMSNRNP200MEN1KMT2ACYP1A2 | |
| SCHEMBL7663981 | 0.87 | LTA4H (0.45) | DRD2KCNA5KCNJ5KCNJ3DYRK1A | |
| SCHEMBL7672395 | 0.85 | PTK2 (0.32) | KCNA5KCNJ5KCNJ3 | |
| SCHEMBL7673339 | 0.84 | MEN1 (0.31) | PKMSNRNP200MEN1KMT2ACYP1A2 | |
| SCHEMBL7669021 | 0.84 | KCNA5 (0.33) | PKMMAPTMEN1KMT2ACYP1A2 | |
| SCHEMBL7672580 | 0.83 | PKM (0.36) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7667021 | 0.83 | ALDH1A1 (0.39) | PKMALDH1A1MAPTHIF1ANPSR1 | |
| SCHEMBL7668793 | 0.83 | HIF1A (0.39) | PKMALDH1A1MAPTHIF1ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |