Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | XPO1 | O14980 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665354 | 0.90 | ALDH1A1 (0.78) | MEN1NPC1KMT2AALDH1A1TSHR | |
| SCHEMBL7668189 | 0.83 | MEN1 (0.88) | MEN1NPC1KMT2AALDH1A1TSHR | |
| SCHEMBL7675868 | 0.79 | POLB (0.80) | KMT2AALDH1A1TSHRMAPTTDP1 | |
| SCHEMBL3017559 | 0.77 | ALDH1A1 (1.00) | MEN1NPC1KMT2AALDH1A1TSHR | |
| SCHEMBL6823671 | 0.76 | MEN1 (0.87) | MEN1NPC1KMT2AALDH1A1TSHR | |
| SCHEMBL7670400 | 0.75 | MAPT (0.67) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL7669067 | 0.68 | MAPT (0.67) | MEN1NPC1KMT2AALDH1A1TSHR | |
| SCHEMBL7668097 | 0.68 | MAPT (0.74) | KMT2AALDH1A1TSHRMAPTKDM4E | |
| SCHEMBL7671937 | 0.67 | POLB (1.00) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL7669614 | 0.67 | MAPT (0.82) | MEN1NPC1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |
| EP-1140875-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037452-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |