Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977489 | 0.96 | GABRA1 (0.41) | GABRA1GABRA5FPR1FPR2MEN1 | |
| SCHEMBL6979201 | 0.90 | GABRA1 (0.41) | GABRA1GABRA5FPR1FPR2MEN1 | |
| SCHEMBL7673131 | 0.89 | GABRA1 (0.39) | GABRA1GABRA5FPR1FPR2MEN1 | |
| SCHEMBL7674354 | 0.87 | GABRA1 (0.39) | GABRA1GABRA5FPR1FPR2MEN1 | |
| SCHEMBL7668963 | 0.85 | GABRA1 (0.36) | GABRA1GABRA5FPR1FPR2MEN1 | |
| SCHEMBL6977199 | 0.85 | GABRA1 (0.39) | GABRA1GABRA5FPR1FPR2MEN1 | |
| SCHEMBL6973743 | 0.85 | PTGDR2 (0.31) | GABRA1GABRA5 | |
| SCHEMBL6980050 | 0.83 | GABRA1 (0.39) | GABRA1GABRA5FPR1FPR2MEN1 | |
| SCHEMBL8153648 | 0.83 | VKORC1 (0.40) | GABRA1GABRA5CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6979202 | 0.83 | HSD17B3 (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |