Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439694 | 0.82 | TSHR (0.52) | TDP1PTGS1TSHRKDM4EATM | |
| SCHEMBL10937484 | 0.78 | PTGS1 (0.51) | PTGS1KMT2ALMNACXCL8PTGS2 | |
| SCHEMBL11419763 | 0.78 | KDM4E (0.47) | TDP1PTGS1TSHRKDM4EATM | |
| SCHEMBL4955520 | 0.78 | TDP1 (0.54) | TDP1TSHRKDM4EATMGAA | |
| SCHEMBL31522017 | 0.77 | TDP1 (0.52) | TDP1TSHRKDM4EATMGAA | |
| SCHEMBL28829625 | 0.77 | TDP1 (0.52) | TDP1TSHRKDM4EATMKMT2A | |
| SCHEMBL28328625 | 0.77 | TDP1 (0.52) | TDP1TSHRKDM4EATMKMT2A | |
| SCHEMBL9715759 | 0.75 | TSHR (0.45) | TDP1PTGS1TSHRKDM4EATM | |
| Dimethyl Phthalate SCHEMBL28487305 | 0.75 | TDP1 (0.65) | TDP1TSHRKDM4EATMKMT2A | |
| SCHEMBL10938264 | 0.74 | CYP1A2 (0.47) | TDP1PTGS1TSHRGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1231939-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001034135-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |