Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 2/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 11/20 | 0.39 |
| ▸ | HTR2B | P41595 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19931095 | 0.79 | RIPK1 (0.38) | RIPK1HTR2CHTR2BHTR2AP2RX3 | |
| SCHEMBL30175236 | 0.77 | HTR2C (0.58) | NOS3NOS1NOS2RIPK1HTR2C | |
| SCHEMBL22470674 | 0.77 | HTR2C (0.58) | NOS3NOS1NOS2RIPK1HTR2C | |
| SCHEMBL15727447 | 0.75 | NOS3 (0.47) | NOS3NOS1NOS2RIPK1HTR2C | |
| SCHEMBL7669934 | 0.75 | PDE4B (0.37) | RIPK1P2RX3AR | |
| SCHEMBL8252603 | 0.73 | RIPK1 (0.63) | NOS3NOS1NOS2RIPK1HTR2C | |
| SCHEMBL20472535 | 0.72 | HTR2C (0.52) | NOS3NOS1NOS2RIPK1HTR2C | |
| SCHEMBL29786347 | 0.72 | HTR2C (0.52) | NOS3NOS1NOS2RIPK1HTR2C | |
| SCHEMBL6213774 | 0.72 | SLC6A4 (0.54) | NOS3NOS1NOS2HTR2CHTR2B | |
| SCHEMBL7664868 | 0.72 | HTR2C (0.51) | NOS3NOS1NOS2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365603-B1 | FOR THERAPY OF PAIN SUCH AS THE PAIN ASSOCIATED WITH JOINT CONDITIONS SUCH AS RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS, POSTOPERATIVE PAIN, POSTPARTUM PAIN, THE PAIN ASSOCIATED WITH DENTAL CONDITIONS SUCH AS DENTAL CARIES AND GINGIVITIS, ETC. | ZENECA LTD. (GB) | 2002-04-02 | — | — | US | disclosed |
| EP-0835246-B1 | AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2001-10-24 | — | — | EP | disclosed |
| US-5994353-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1999-11-30 | — | — | US | disclosed |
| EP-0835246-A1 | AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZENECA LIMITED (GB) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997000863-A1 | AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZENECA LIMITED (GB) | 1997-01-09 | — | — | WO | disclosed |