Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACA | Q13085 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GUSB | P08236 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23496991 | 0.88 | TLR8 (0.53) | ACACAACVR1AAK1ERN1GAK | |
| SCHEMBL12989150 | 0.87 | CYP1A1 (0.52) | ACACAMEN1KMT2AACVR1AAK1 | |
| SCHEMBL7418556 | 0.85 | PDE4A (0.54) | — | |
| SCHEMBL11822911 | 0.84 | PDGFRB (0.57) | ACVR1GAKRIPK2COQ8ANLK | |
| SCHEMBL11808233 | 0.81 | TLR8 (0.60) | ACACAAAK1NPC1SMN1; SMN2GAK | |
| SCHEMBL16549179 | 0.81 | KIT (0.48) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL30251801 | 0.80 | BMP4 (0.61) | ACACAMEN1KMT2AACVR1L3MBTL1 | |
| SCHEMBL7665284 | 0.80 | BMP4 (0.61) | ACACAMEN1KMT2AACVR1L3MBTL1 | |
| SCHEMBL27290306 | 0.79 | CLK4 (0.53) | ACACAKMT2AACVR1ALDH1A1HPGD | |
| SCHEMBL29269603 | 0.78 | ALDH1A1 (0.51) | ACVR1KDM4ENPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6388081-B1 | 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries | LION BIOSCIENCE AG (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6262269-B1 | 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries | TREGA BIOSCIENCES, INC. | 2001-07-17 | — | — | US | disclosed |
| EP-0977989-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998034115-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | disclosed |
| US-3936461-A | Substituted 4-benzylquinolines | WARNER-LAMBERT COMPANY (US) | 1976-02-03 | — | — | US | disclosed |