Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP4 | P12644 | 3/20 | 0.61 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.60 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.60 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.60 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.60 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.60 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.60 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.60 |
| ▸ | ACACA | Q13085 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30251801 | 1.00 | BMP4 (0.61) | BMP4ACVR1BMPR1BKDRBMPR1A | |
| SCHEMBL8027506 | 0.89 | ACVR1 (0.60) | BMP4ACVR1BMPR1BKDRBMPR1A | |
| SCHEMBL18774844 | 0.88 | BMP4 (0.59) | BMP4ACVR1BMPR1BKDRBMPR1A | |
| SCHEMBL27290306 | 0.83 | CLK4 (0.53) | BMP4ACVR1BMPR1BKDRBMPR1A | |
| SCHEMBL2603403 | 0.81 | KDM4E (0.56) | BMP4ACVR1BMPR1BKDRBMPR1A | |
| SCHEMBL29492647 | 0.81 | NPC1 (0.55) | ACVR1TGFBR1HTTKCNH2GRM4 | |
| SCHEMBL5314423 | 0.81 | NPC1 (0.55) | ACVR1TGFBR1HTTKCNH2GRM4 | |
| SCHEMBL30440258 | 0.81 | PIK3CA (0.57) | ACACATLR8KCNH2GRM4ALDH1A1 | |
| SCHEMBL9159084 | 0.81 | GRM4 (0.67) | ACACATLR8KCNH2GRM4ALDH1A1 | |
| SCHEMBL12074333 | 0.80 | PIK3CA (0.65) | BMP4ACVR1KDRTGFBR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118345389-A | Green synthesis method of silicon-based substituted quinoline derivative | 江苏食品药品职业技术学院 | 2024-07-16 | — | — | CN | disclosed |
| CN-115715292-A | 1H-pyrazolo [4,3-g ] isoquinoline and 1H-pyrazolo [4,3-g ] quinoline derivatives as alpha-1-antitrypsin modulators for the treatment of alpha-1-antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-24 | — | — | CN | disclosed |
| US-20150376182-A1 | Substituted Acetylene Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2015-12-31 | — | — | US | disclosed |
| US-6388081-B1 | 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries | LION BIOSCIENCE AG (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6262269-B1 | 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries | TREGA BIOSCIENCES, INC. | 2001-07-17 | — | — | US | disclosed |
| EP-0977989-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998034115-A1 | 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376182-A1 | Substituted Acetylene Derivatives and their Use as Positive Allosteric Modulators of mGluR4 | GRM4, GRIA4, GRIK4 | BMP4 1916/4885ACVR1 2990/4885BMPR1B 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.