Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668613 | 0.97 | LTA4H (0.46) | LTA4HCHRNB2CHRNA4PDE4DKDM4E | |
| SCHEMBL7661834 | 0.91 | LTA4H (0.43) | LTA4HCHRNB2CHRNA4PDE4DKDM4E | |
| SCHEMBL7672387 | 0.89 | LTA4H (0.43) | LTA4HCHRNB2CHRNA4PDE4DKDM4E | |
| SCHEMBL7674840 | 0.88 | KCNA5 (0.39) | KCNA5KCNJ5KCNJ3RIPK1ALDH1A1 | |
| SCHEMBL7668793 | 0.88 | HIF1A (0.39) | KCNA5KCNJ5KCNJ3RIPK1ALDH1A1 | |
| SCHEMBL7672547 | 0.86 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4PDE4DKDM4E | |
| SCHEMBL7667052 | 0.86 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4PDE4DKDM4E | |
| SCHEMBL7664000 | 0.86 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4PDE4DKDM4E | |
| SCHEMBL7668136 | 0.86 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4PDE4DKDM4E | |
| SCHEMBL7663981 | 0.86 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4PDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |