Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672547 | 0.94 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4SIGMAR1KDM4E | |
| SCHEMBL7668596 | 0.87 | RIPK1 (0.35) | RIPK1 | |
| SCHEMBL7673275 | 0.87 | PKM (0.36) | RIPK1MAOB | |
| SCHEMBL7669084 | 0.86 | LTA4H (0.46) | LTA4HCHRNB2CHRNA4SIGMAR1KDM4E | |
| SCHEMBL7668613 | 0.86 | LTA4H (0.46) | LTA4HCHRNB2CHRNA4SIGMAR1KDM4E | |
| SCHEMBL7667052 | 0.85 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4SIGMAR1KDM4E | |
| SCHEMBL7667087 | 0.85 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4SIGMAR1KDM4E | |
| SCHEMBL7661805 | 0.85 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4SIGMAR1KDM4E | |
| SCHEMBL7670688 | 0.84 | RIPK1 (0.38) | GAARIPK1 | |
| SCHEMBL7664000 | 0.84 | LTA4H (0.45) | LTA4HCHRNB2CHRNA4SIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |