Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 14/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 13/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 13/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668727 | 0.97 | KCNA5 (0.39) | KCNA5KCNJ5KCNJ3RIPK1FPR1 | |
| SCHEMBL7668793 | 0.90 | HIF1A (0.39) | KCNA5KCNJ5KCNJ3RIPK1FPR1 | |
| SCHEMBL7673892 | 0.90 | FPR1 (0.34) | KCNA5KCNJ5KCNJ3RIPK1FPR1 | |
| SCHEMBL7674363 | 0.88 | FPR1 (0.34) | KCNA5KCNJ5KCNJ3RIPK1FPR1 | |
| SCHEMBL7669084 | 0.88 | LTA4H (0.46) | KCNA5KCNJ5KCNJ3RIPK1ALDH1A1 | |
| SCHEMBL7667021 | 0.87 | ALDH1A1 (0.39) | KCNA5KCNJ5KCNJ3RIPK1FPR1 | |
| SCHEMBL7668613 | 0.85 | LTA4H (0.46) | KCNA5KCNJ5KCNJ3RIPK1ALDH1A1 | |
| SCHEMBL7668596 | 0.84 | RIPK1 (0.35) | RIPK1FPR1FPR2CYP1A2CYP3A4 | |
| SCHEMBL7672522 | 0.84 | RIPK1 (0.33) | RIPK1FPR1FPR2CYP1A2CYP3A4 | |
| SCHEMBL7669113 | 0.84 | RIPK1 (0.33) | KCNA5KCNJ5KCNJ3RIPK1FPR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |