SCHEMBL7669251

SCHEMBL7669251

O=C(O)C[C@H](NS(=O)(=O)c1ccc(NC(=O)c2ccccc2)cc1)C(=O)O

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 8/20 0.76
MMP2 P08253 8/20 0.64
MMP3 P08254 3/20 0.59
MMP13 P45452 3/20 0.59
LMNA P02545 1/20 0.59
PRMT1 Q99873 1/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
CA12 O43570 1/20 0.55
CA1 P00915 1/20 0.55
CA2 P00918 1/20 0.55
CA9 Q16790 1/20 0.55
HPGD P15428 1/20 0.55
ITGB3 P05106 1/20 0.53
ITGB1 P05556 1/20 0.53
ITGAV P06756 1/20 0.53
ITGA2B P08514 1/20 0.53
ITGB5 P18084 1/20 0.53
MMP8 P22894 1/20 0.53
MMP12 P39900 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7669603 1.00 MMP9 (0.76) MMP9MMP2MMP3MMP13LMNA
SCHEMBL4834471 0.88 MMP9 (0.72) MMP9MMP2MMP3MMP13LMNA
SCHEMBL7669560 0.88 MMP9 (0.72) MMP9MMP2MMP3MMP13LMNA
SCHEMBL4828175 0.87 MMP9 (0.59) MMP9MMP2MMP3MMP13LMNA
SCHEMBL7665921 0.87 ITGB3 (0.60) MMP9MMP2MMP3MMP13CA1
SCHEMBL7675244 0.86 MMP9 (1.00) MMP9MMP2MMP3MMP13ITGB3
SCHEMBL7668862 0.86 MMP9 (1.00) MMP9MMP2MMP3MMP13ITGB3
SCHEMBL7673418 0.85 MMP9 (0.72) MMP9MMP2MMP3MMP13LMNA
SCHEMBL7668182 0.85 MMP9 (0.72) MMP9MMP2MMP3MMP13LMNA
SCHEMBL4824760 0.85 KMT2A (0.61) MMP9LMNAMEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6403644-B1 FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS ONO PHARMACEUTICAL CO., LTD. (JP) 2002-06-11 US claimed
EP-0757037-A2 Sulfonylamino acid derivatives as metalloproteinase inhibitors ONO PHARMACEUTICAL CO., LTD. (JP) 1997-02-05 EP claimed
US-6403644-B1 FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS ONO PHARMACEUTICAL CO., LTD. (JP) 2002-06-11 US disclosed
US-6177466-B1 Sulfonylamino acid derivatives ONO PHARMACEUTICAL CO., LTD. (JP) 2001-01-23 US disclosed
EP-0757037-A2 Sulfonylamino acid derivatives as metalloproteinase inhibitors ONO PHARMACEUTICAL CO., LTD. (JP) 1997-02-05 EP disclosed