SCHEMBL7669752

SCHEMBL7669752

O=C(NCCC(NC(=O)c1cccc(O)c1O)C(=O)O)c1cccc(O)c1O

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 7/20 0.59
TERT O14746 2/20 0.44
ALDH1A1 P00352 3/20 0.43
HPGD P15428 3/20 0.43
HSD17B10 Q99714 3/20 0.43
TSHR P16473 2/20 0.43
NPC1 O15118 1/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
NLRP1 Q9C000 1/20 0.43
FOLH1 Q04609 2/20 0.41
HDAC7 Q8WUI4 1/20 0.41
NAAA Q02083 1/20 0.40
KDM4E B2RXH2 2/20 0.40
LMNA P02545 2/20 0.40
EPHX2 P34913 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7668122 0.92 ALOX5 (0.64) ALOX5TERTALDH1A1HPGDHSD17B10
SCHEMBL8488937 0.92 ALOX5 (0.64) ALOX5TERTALDH1A1HPGDHSD17B10
SCHEMBL3441243 0.91 ALOX5 (0.67) ALOX5ALDH1A1HPGDHSD17B10TSHR
SCHEMBL8487740 0.91 ALOX5 (0.67) ALOX5ALDH1A1HPGDHSD17B10TSHR
SCHEMBL18196585 0.86 ALOX5 (0.62) ALOX5ALDH1A1HPGDHSD17B10TSHR
SCHEMBL18196763 0.86 ALOX5 (0.45) ALOX5ALDH1A1HPGDHSD17B10TSHR
SCHEMBL8488000 0.85 ALOX5 (0.54) ALOX5TERTALDH1A1HPGDHSD17B10
SCHEMBL8487702 0.85 ALOX5 (0.54) ALOX5TERTALDH1A1HPGDHSD17B10
SCHEMBL21579768 0.84 TAS1R3 (0.50) ALOX5TERTALDH1A1HPGDHSD17B10
SCHEMBL8487914 0.84 CA2 (0.52) ALOX5TERTHPGDFOLH1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6380181-B1 AMINO ACID RESIDUES IN THE 3-AND/OR 4-POSITION FUNCTION AS SIDEROPHORES AND/OR AS BIOLOGICAL CHELATING AGENTS FOR IRON IN GRAM-NEGATIVE BACTERIA GRUENENTHAL GMBH (DE) 2002-04-30 US disclosed