Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.48 |
| ▸ | GPR27 | Q9NS67 | 6/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671600 | 0.88 | ALDH1A1 (0.51) | ALDH1A1LMNASMN1; SMN2KMT2AHSD17B10 | |
| SCHEMBL7665180 | 0.87 | KDM4E (0.56) | TP53POLBLMNASMN1; SMN2KMT2A | |
| SCHEMBL7669835 | 0.86 | RXFP1 (0.61) | TP53POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7669734 | 0.85 | MEN1 (0.52) | TP53POLBALDH1A1LMNAKMT2A | |
| SCHEMBL7669548 | 0.84 | ALDH1A1 (0.64) | POLBALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL7582747 | 0.84 | LMNA (0.65) | POLBALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL7675575 | 0.83 | TP53 (0.65) | TP53POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7675914 | 0.83 | LMNA (0.65) | TP53LMNASMN1; SMN2MAPTGAA | |
| SCHEMBL7663139 | 0.82 | POLB (0.62) | POLBALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL7671859 | 0.82 | PRMT1 (0.56) | TP53POLBALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |