Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665180 | 0.88 | KDM4E (0.56) | HTTHSD17B10KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL7670478 | 0.88 | TP53 (0.56) | ALDH1A1HSD17B10SMN1; SMN2GAAKMT2A | |
| SCHEMBL7669835 | 0.87 | RXFP1 (0.61) | ALDH1A1HSD17B10SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7669734 | 0.86 | MEN1 (0.52) | ALDH1A1HTTHSD17B10KDM4ENPC1 | |
| SCHEMBL7669548 | 0.85 | ALDH1A1 (0.64) | ALDH1A1HTTHSD17B10SMN1; SMN2RAB9A | |
| SCHEMBL7582747 | 0.85 | LMNA (0.65) | ALDH1A1SMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL7663119 | 0.83 | FFAR1 (0.60) | ALDH1A1HTTHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL7663740 | 0.83 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL7675460 | 0.83 | SGMS2 (0.58) | ALDH1A1HSD17B10MEN1GAAKMT2A | |
| SCHEMBL7669640 | 0.82 | GHSR (0.53) | ALDH1A1HTTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |