Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 9/20 | 0.87 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.69 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.64 |
| ▸ | ITGAV | P06756 | 3/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.64 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.64 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.64 |
| ▸ | MMP2 | P08253 | 9/20 | 0.60 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | MMP7 | P09237 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673966 | 1.00 | MMP9 (0.87) | MMP9MEN1KMT2AL3MBTL1ITGB3 | |
| SCHEMBL7668862 | 0.93 | MMP9 (1.00) | MMP9ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7675244 | 0.93 | MMP9 (1.00) | MMP9ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL14191415 | 0.90 | MMP9 (0.93) | MMP9ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7665147 | 0.88 | MMP9 (0.71) | MMP9MEN1KMT2AL3MBTL1ITGB3 | |
| SCHEMBL7663396 | 0.88 | MMP9 (0.71) | MMP9MEN1KMT2AL3MBTL1ITGB3 | |
| SCHEMBL5093780 | 0.85 | MMP9 (1.00) | MMP9ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7669356 | 0.85 | MMP9 (1.00) | MMP9ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL8912956 | 0.85 | L3MBTL1 (0.78) | MMP9MEN1KMT2AL3MBTL1MMP2 | |
| SCHEMBL14191416 | 0.85 | MMP9 (0.84) | MMP9MEN1KMT2AL3MBTL1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |