Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631863 | 1.00 | MTNR1A (0.46) | MTNR1ALMNAFFAR1SMN1; SMN2MAPT | |
| SCHEMBL1041765 | 0.95 | MTNR1A (0.51) | MTNR1ALMNAFFAR1SMN1; SMN2MAPT | |
| SCHEMBL6895073 | 0.95 | MTNR1A (0.51) | MTNR1ALMNAFFAR1SMN1; SMN2MAPT | |
| SCHEMBL10832816 | 0.89 | CA2 (0.51) | LMNAFFAR1SMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL11102654 | 0.86 | LMNA (0.48) | LMNAFFAR1SMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL1043582 | 0.85 | CA2 (0.46) | MTNR1ALMNAFFAR1SMN1; SMN2MAPT | |
| SCHEMBL9369808 | 0.85 | CA2 (0.53) | LMNAFFAR1SMN1; SMN2MAPTCYP3A4 | |
| SCHEMBL1117923 | 0.85 | CA2 (0.53) | LMNAFFAR1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL13646367 | 0.85 | CA2 (0.53) | LMNAFFAR1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL6629428 | 0.85 | CA2 (0.53) | LMNAFFAR1SMN1; SMN2MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458802-B1 | ANTIDEPRESSANTS, OBSESSIVE COMPULSIVE DISORDER, DIETETICS | WYETH | 2002-10-01 | — | — | US | disclosed |
| EP-0445026-B1 | Aminomethylpiperidine derivatives, their process for preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1994-01-26 | — | — | EP | disclosed |
| US-5229399-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-07-20 | — | — | US | disclosed |
| US-5229398-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-07-20 | — | — | US | disclosed |
| US-5192775-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-03-09 | — | — | US | disclosed |
| EP-0445026-A1 | Aminomethylpiperidine derivatives, their process for preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-09-04 | — | — | EP | disclosed |